Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl and pyridoxal-5-phosphate)
50 mg
2,941%
Top Medical Research Studies
9
We explored the potential of vitamin B6 (VB6) in promoting recovery after heart attacks, specifically its role in angiogenesis, which is the formation of new blood vessels. The study aimed to determine whether VB6 could help prevent cardiac dysfunction following acute myocardial infarction (AMI).
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
Read More
9
We investigated the potential of pyridoxamine, a form of vitamin B6, to improve outcomes after a heart attack (myocardial infarction, or MI). In our study, we divided rats into three groups: one that suffered from MI, another that also received pyridoxamine, and a sham group for comparison.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Read More
4
We explored the potential benefits of vitamin B6, specifically pyridoxamine, in conjunction with heart stem cells known as cardiac atrial appendage stem cells (CASCs) for recovery after a heart attack. In our study, we induced a heart attack in rats by blocking a key artery, then divided them into three groups: one with no treatment, one receiving CASCs alone, and another receiving CASCs along with pyridoxamine.
Our findings revealed that CASCs transplantation significantly improved heart function and reduced damage from the heart attack. While we did see that pyridoxamine effectively lowered levels of harmful substances called advanced glycation end products (AGEs) in the heart, it did not enhance the benefits achieved by the CASCs.
Ultimately, our results suggest that simply adding vitamin B6 to stem cell therapy may not offer additional advantages in healing the heart after a serious injury like a heart attack. This raises important questions about the specific role of AGEs in the effectiveness of stem cell treatments.
Our findings revealed that CASCs transplantation significantly improved heart function and reduced damage from the heart attack. While we did see that pyridoxamine effectively lowered levels of harmful substances called advanced glycation end products (AGEs) in the heart, it did not enhance the benefits achieved by the CASCs.
Ultimately, our results suggest that simply adding vitamin B6 to stem cell therapy may not offer additional advantages in healing the heart after a serious injury like a heart attack. This raises important questions about the specific role of AGEs in the effectiveness of stem cell treatments.
Read More
Most Useful Reviews
9
Heart health improvement
Powerful supplement for heart health. It contributed to my overall heart health and helped lower my blood pressure when combined with diet and exercise changes.
Read More
7.5
Mood enhancement
Vitamin B6 plays a vital role in maintaining the nervous system and aids in red blood cell formation. After taking it, I noticed an improvement in my mood and a reduction in stress, which is beneficial for conditions like heart attack. It's also good for skin and heart health.
Read More
7.5
Prevention of diseases
Vitamin B6 is crucial for the body's biochemical processes and helps maintain normal cholesterol levels. It's vital for the heart muscle's function and can prevent serious diseases like thrombosis and heart attack. It also supports the immune system.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.2
- All Researches
9
We explored the potential of vitamin B6 (VB6) in promoting recovery after heart attacks, specifically its role in angiogenesis, which is the formation of new blood vessels. The study aimed to determine whether VB6 could help prevent cardiac dysfunction following acute myocardial infarction (AMI).
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
Read More
9
We investigated the potential of pyridoxamine, a form of vitamin B6, to improve outcomes after a heart attack (myocardial infarction, or MI). In our study, we divided rats into three groups: one that suffered from MI, another that also received pyridoxamine, and a sham group for comparison.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Read More
7
We conducted a study to find out how vitamin B6, particularly in combination with other treatments, affects heart attack outcomes. Our research involved 80 participants who were monitored for various health markers over a year. We had an experimental group that received standard ischemic heart disease (IHD) treatment along with ampicillin, vitamin B complex, including B6, and other vitamins.
What we found is quite interesting. The treatment group showed a moderate improvement in the systolic function of the heart compared to those who didn’t receive vitamin B6 and additional treatments. Importantly, there was a significant reduction in major adverse cardiac events (MACE) for this group, highlighting a potential anti-inflammatory effect from the treatment regimen.
However, while vitamin B6 was part of this treatment package, we noted that it was challenging to assess its isolated impact on heart attack outcomes. This means that while we saw promising results, we can't definitively say how much of the benefit was directly due to vitamin B6 alone.
What we found is quite interesting. The treatment group showed a moderate improvement in the systolic function of the heart compared to those who didn’t receive vitamin B6 and additional treatments. Importantly, there was a significant reduction in major adverse cardiac events (MACE) for this group, highlighting a potential anti-inflammatory effect from the treatment regimen.
However, while vitamin B6 was part of this treatment package, we noted that it was challenging to assess its isolated impact on heart attack outcomes. This means that while we saw promising results, we can't definitively say how much of the benefit was directly due to vitamin B6 alone.
Read More
7
MTHFD1 polymorphism and heart attack
We explored the link between a specific genetic variation in the MTHFD1 gene and the risk of heart attacks, or acute myocardial infarctions (AMI), in patients with stable angina pectoris. Our team looked at data from 2,381 participants in a randomized trial where some were treated with vitamins B6, folic acid, and B12, while others received a placebo. Over an average follow-up period of 4.9 years, we noted that about 8.6% of the participants experienced a heart attack.
The results revealed that individuals with the MTHFD1 genetic variation had a significantly higher risk of experiencing an AMI, especially among those treated with vitamin B6 alone or with both vitamin B6 and folic acid/B12. In fact, those on combined vitamin treatment faced an even greater risk. However, for participants receiving either a placebo or folic acid/B12 alone, no substantial connection between the MTHFD1 variation and heart attack risk was observed.
Overall, our findings suggest that the risk associated with the MTHFD1 genotype is influenced by vitamin B6 treatment. This invites further investigation into how vitamins and nutritional factors may affect heart health and genetic predispositions.
The results revealed that individuals with the MTHFD1 genetic variation had a significantly higher risk of experiencing an AMI, especially among those treated with vitamin B6 alone or with both vitamin B6 and folic acid/B12. In fact, those on combined vitamin treatment faced an even greater risk. However, for participants receiving either a placebo or folic acid/B12 alone, no substantial connection between the MTHFD1 variation and heart attack risk was observed.
Overall, our findings suggest that the risk associated with the MTHFD1 genotype is influenced by vitamin B6 treatment. This invites further investigation into how vitamins and nutritional factors may affect heart health and genetic predispositions.
Read More
7
We explored the effectiveness of vitamin B6 in preventing heart attacks through a systematic review and meta-analysis of randomized controlled trials. This involved analyzing data from 50 studies that included nearly 300,000 participants. Our findings indicated that supplementation with vitamin B6 showed a small decrease in the risk of major cardiovascular events; however, this effect appeared primarily in studies deemed to be of lower quality.
Interestingly, while some studies suggested a potential link between vitamin B6 and a reduced risk of cardiovascular death, these benefits predominantly surfaced in trials supported by the pharmaceutical industry. In conclusion, it's important to highlight that there was no consistent evidence to support the use of vitamin B6 or other vitamin and antioxidant supplements in preventing heart disease overall. The results need careful interpretation, especially given that the beneficial effects reported were less convincing in high-quality trials.
Overall, our assessment suggests that while vitamin B6 might have some minor beneficial aspects regarding heart attack risk, the broader implications for using such supplements in heart disease prevention remain unclear and unsubstantiated.
Interestingly, while some studies suggested a potential link between vitamin B6 and a reduced risk of cardiovascular death, these benefits predominantly surfaced in trials supported by the pharmaceutical industry. In conclusion, it's important to highlight that there was no consistent evidence to support the use of vitamin B6 or other vitamin and antioxidant supplements in preventing heart disease overall. The results need careful interpretation, especially given that the beneficial effects reported were less convincing in high-quality trials.
Overall, our assessment suggests that while vitamin B6 might have some minor beneficial aspects regarding heart attack risk, the broader implications for using such supplements in heart disease prevention remain unclear and unsubstantiated.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Heart health improvement
Powerful supplement for heart health. It contributed to my overall heart health and helped lower my blood pressure when combined with diet and exercise changes.
Read More
7.5
Mood enhancement
Vitamin B6 plays a vital role in maintaining the nervous system and aids in red blood cell formation. After taking it, I noticed an improvement in my mood and a reduction in stress, which is beneficial for conditions like heart attack. It's also good for skin and heart health.
Read More
7.5
Prevention of diseases
Vitamin B6 is crucial for the body's biochemical processes and helps maintain normal cholesterol levels. It's vital for the heart muscle's function and can prevent serious diseases like thrombosis and heart attack. It also supports the immune system.
Read More
7.5
Essential for heart
An essential vitamin for the heart, especially when combined with magnesium. Convenient capsules make it easy to take.
Read More
Frequently Asked Questions
9
Heart health improvement
Powerful supplement for heart health. It contributed to my overall heart health and helped lower my blood pressure when combined with diet and exercise changes.
7.5
Mood enhancement
Vitamin B6 plays a vital role in maintaining the nervous system and aids in red blood cell formation. After taking it, I noticed an improvement in my mood and a reduction in stress, which is beneficial for conditions like heart attack. It's also good for skin and heart health.
7.5
Prevention of diseases
Vitamin B6 is crucial for the body's biochemical processes and helps maintain normal cholesterol levels. It's vital for the heart muscle's function and can prevent serious diseases like thrombosis and heart attack. It also supports the immune system.
7.5
Essential for heart
An essential vitamin for the heart, especially when combined with magnesium. Convenient capsules make it easy to take.
9
We explored the potential of vitamin B6 (VB6) in promoting recovery after heart attacks, specifically its role in angiogenesis, which is the formation of new blood vessels. The study aimed to determine whether VB6 could help prevent cardiac dysfunction following acute myocardial infarction (AMI).
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
To assess the effects of VB6, we conducted both in vitro experiments, examining endothelial cell behavior, and in vivo tests using mice with heart attacks. We discovered that VB6 significantly enhanced cell migration and tubule formation in human umbilical vein endothelial cells, which are critical for blood vessel formation. This process was linked to increased activity of a protein called AMP-activated protein kinase (AMPK).
Interestingly, our findings showed that these beneficial effects of VB6 were reversed when we introduced AMPK inhibitors. This leads us to conclude that VB6 promotes heart recovery by activating AMPK, which in turn supports angiogenesis following AMI. In practical terms, long-term VB6 supplementation after heart attacks led to improved heart function and increased new blood vessel formation in mice, making this vitamin a promising candidate for heart recovery therapies.
9
We investigated the potential of pyridoxamine, a form of vitamin B6, to improve outcomes after a heart attack (myocardial infarction, or MI). In our study, we divided rats into three groups: one that suffered from MI, another that also received pyridoxamine, and a sham group for comparison.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
Over the course of eight weeks, we observed how these treatments impacted heart function using echocardiography and hemodynamic assessments. Remarkably, we found that pyridoxamine not only enhanced survival rates post-heart attack but also significantly reduced harmful levels of advanced glycation end products (AGEs) – compounds that can lead to heart failure.
Specifically, rats treated with pyridoxamine exhibited lower left ventricular pressures and improved heart deformation parameters compared to untreated rats. This better heart function was linked to a decrease in collagen in heart tissue, especially around the damaged area, which is crucial because excess collagen can worsen heart stiffness.
Overall, our findings suggest that pyridoxamine could be a promising therapy for preventing detrimental heart changes following a heart attack, highlighting the value of targeting AGEs in treatment strategies.
7
We explored the effectiveness of vitamin B6 in preventing heart attacks through a systematic review and meta-analysis of randomized controlled trials. This involved analyzing data from 50 studies that included nearly 300,000 participants. Our findings indicated that supplementation with vitamin B6 showed a small decrease in the risk of major cardiovascular events; however, this effect appeared primarily in studies deemed to be of lower quality.
Interestingly, while some studies suggested a potential link between vitamin B6 and a reduced risk of cardiovascular death, these benefits predominantly surfaced in trials supported by the pharmaceutical industry. In conclusion, it's important to highlight that there was no consistent evidence to support the use of vitamin B6 or other vitamin and antioxidant supplements in preventing heart disease overall. The results need careful interpretation, especially given that the beneficial effects reported were less convincing in high-quality trials.
Overall, our assessment suggests that while vitamin B6 might have some minor beneficial aspects regarding heart attack risk, the broader implications for using such supplements in heart disease prevention remain unclear and unsubstantiated.
Interestingly, while some studies suggested a potential link between vitamin B6 and a reduced risk of cardiovascular death, these benefits predominantly surfaced in trials supported by the pharmaceutical industry. In conclusion, it's important to highlight that there was no consistent evidence to support the use of vitamin B6 or other vitamin and antioxidant supplements in preventing heart disease overall. The results need careful interpretation, especially given that the beneficial effects reported were less convincing in high-quality trials.
Overall, our assessment suggests that while vitamin B6 might have some minor beneficial aspects regarding heart attack risk, the broader implications for using such supplements in heart disease prevention remain unclear and unsubstantiated.
References
- Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413
- Evens L, Beliën H, D'Haese S, Haesen S, Verboven M, et al. Combinational Therapy of Cardiac Atrial Appendage Stem Cells and Pyridoxamine: The Road to Cardiac Repair?. Int J Mol Sci. 2021;22. doi:10.3390/ijms22179266
- Hodzic E. Potential Anti-Inflammatory Treatment of Ischemic Heart Disease. Med Arch. 2018;72:94. doi:10.5455/medarh.2018.72.94-98
- Deluyker D, Ferferieva V, Driesen RB, Verboven M, Lambrichts I, et al. Pyridoxamine improves survival and limits cardiac dysfunction after MI. Sci Rep. 2017;7:16010. doi:10.1038/s41598-017-16255-y
- Ding YP, Pedersen EK, Johansson S, Gregory JF, Ueland PM, et al. B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris. Nutr Metab Cardiovasc Dis. 2016;26:495. doi:10.1016/j.numecd.2015.12.009
- Myung SK, Ju W, Cho B, Oh SW, Park SM, et al. Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials. BMJ. 2013;346:f10. doi:10.1136/bmj.f10
